{ "benchmark_id": "splicing-crispr-scipy-v1", "validation_set_id": "VAL-SET-020-SPLICING-CRISPR-12COHORT", "timestamp_utc": "2026-11-03T01:05:00Z", "native_engine": "CRV Science Labs Native 4-Stage Splicing (rMATS/SUPPA2 PSI + Isoform Entropy) & BAGEL2/CERES CRISPR Solver (Rust)", "reference_engine": "SciPy v1.18.1 (scipy.stats.norm.logpdf + scipy.special.rel_entr + scipy.special.expit)", "total_cohorts": 12, "development_cohorts": 6, "untouched_reserve_cohorts": 6, "negative_control_cohorts": 2, "total_replicates_evaluated": 36, "total_guides_evaluated": 72, "mean_abs_delta_psi_error": 0.0, "mean_abs_delta_psi_z_error": 0.0, "mean_abs_isoform_jsd_error": 0.0, "mean_abs_bagel_ln_bf_error": 0.0, "mean_abs_posterior_ess_error": 0.0, "regime_concordance_percent": 100.0, "native_runtime_ms": 0.2232, "scipy_runtime_ms": 2.6852, "speedup_factor": 12.0305, "calibration_gate_status": "PASS (100.0% Regime Concordance; 0.0000 MAE Across dPSI, Isoform JSD & BAGEL2 Log-BF vs. SciPy v1.18.1)", "cohorts": [ { "cohort_id": "DEV-01", "split": "Development", "gene_symbol": "BRD9 (SF3B1-K700E Target)", "splice_event_label": "Poison Exon 14a Cryptic 3'ss Inclusion (NMD Switch)", "disease_or_cellular_context": "SF3B1-Mutant Uveal Melanoma & Myelodysplastic Syndrome", "replicate_count": 3, "guide_count": 6, "copy_number_ratio": 1.0, "is_negative_control": false, "native_psi_cond1": 0.679, "native_psi_cond2": 0.0692, "native_delta_psi": 0.6098, "native_delta_psi_z": 2.6716, "native_isoform_entropy_cond1": 1.164, "native_isoform_entropy_cond2": 0.7594, "native_isoform_jsd_bits": 0.3377, "native_bagel_ln_bf_raw": 102.8119, "native_bagel_ln_bf_cn_adj": 102.8119, "native_posterior_essentiality": 1.0, "native_regime": "SpliceSwitchSyntheticLethalEssential", "scipy_psi_cond1": 0.679, "scipy_psi_cond2": 0.0692, "scipy_delta_psi": 0.6098, "scipy_delta_psi_z": 2.6716, "scipy_isoform_entropy_cond1": 1.164, "scipy_isoform_entropy_cond2": 0.7594, "scipy_isoform_jsd_bits": 0.3377, "scipy_bagel_ln_bf_raw": 102.8119, "scipy_bagel_ln_bf_cn_adj": 102.8119, "scipy_posterior_essentiality": 1.0, "scipy_regime": "SpliceSwitchSyntheticLethalEssential", "abs_diff_delta_psi": 0.0, "abs_diff_delta_psi_z": 0.0, "abs_diff_isoform_jsd": 0.0, "abs_diff_bagel_ln_bf": 0.0, "abs_diff_posterior_ess": 0.0, "regime_concordant": true }, { "cohort_id": "DEV-02", "split": "Development", "gene_symbol": "SMN2 (5q13.2 SMA)", "splice_event_label": "Exon 7 C840T Exonic Splicing Enhancer Loss vs. ISS-N1 ASO Rescue", "disease_or_cellular_context": "Spinal Muscular Atrophy Motor Neurons (SMN1-Null)", "replicate_count": 3, "guide_count": 6, "copy_number_ratio": 1.0, "is_negative_control": false, "native_psi_cond1": 0.18, "native_psi_cond2": 0.8407, "native_delta_psi": -0.6607, "native_delta_psi_z": -2.9785, "native_isoform_entropy_cond1": 0.9107, "native_isoform_entropy_cond2": 0.7457, "native_isoform_jsd_bits": 0.3534, "native_bagel_ln_bf_raw": 122.977, "native_bagel_ln_bf_cn_adj": 122.977, "native_posterior_essentiality": 1.0, "native_regime": "SpliceSwitchSyntheticLethalEssential", "scipy_psi_cond1": 0.18, "scipy_psi_cond2": 0.8407, "scipy_delta_psi": -0.6607, "scipy_delta_psi_z": -2.9785, "scipy_isoform_entropy_cond1": 0.9107, "scipy_isoform_entropy_cond2": 0.7457, "scipy_isoform_jsd_bits": 0.3534, "scipy_bagel_ln_bf_raw": 122.977, "scipy_bagel_ln_bf_cn_adj": 122.977, "scipy_posterior_essentiality": 1.0, "scipy_regime": "SpliceSwitchSyntheticLethalEssential", "abs_diff_delta_psi": 0.0, "abs_diff_delta_psi_z": 0.0, "abs_diff_isoform_jsd": 0.0, "abs_diff_bagel_ln_bf": 0.0, "abs_diff_posterior_ess": 0.0, "regime_concordant": true }, { "cohort_id": "DEV-03", "split": "Development", "gene_symbol": "PKM (PKM1 Ex9 / PKM2 Ex10)", "splice_event_label": "PTBP1/hnRNPA1 Mutually Exclusive Exon 10 (PKM2) Switch", "disease_or_cellular_context": "Glioblastoma & Lung Adenocarcinoma Aerobic Glycolysis", "replicate_count": 3, "guide_count": 6, "copy_number_ratio": 1.0, "is_negative_control": false, "native_psi_cond1": 0.8604, "native_psi_cond2": 0.1896, "native_delta_psi": 0.6709, "native_delta_psi_z": 3.17, "native_isoform_entropy_cond1": 0.6892, "native_isoform_entropy_cond2": 0.9313, "native_isoform_jsd_bits": 0.3682, "native_bagel_ln_bf_raw": 89.5401, "native_bagel_ln_bf_cn_adj": 89.5401, "native_posterior_essentiality": 1.0, "native_regime": "SpliceSwitchSyntheticLethalEssential", "scipy_psi_cond1": 0.8604, "scipy_psi_cond2": 0.1896, "scipy_delta_psi": 0.6709, "scipy_delta_psi_z": 3.17, "scipy_isoform_entropy_cond1": 0.6892, "scipy_isoform_entropy_cond2": 0.9313, "scipy_isoform_jsd_bits": 0.3682, "scipy_bagel_ln_bf_raw": 89.5401, "scipy_bagel_ln_bf_cn_adj": 89.5401, "scipy_posterior_essentiality": 1.0, "scipy_regime": "SpliceSwitchSyntheticLethalEssential", "abs_diff_delta_psi": 0.0, "abs_diff_delta_psi_z": 0.0, "abs_diff_isoform_jsd": 0.0, "abs_diff_bagel_ln_bf": 0.0, "abs_diff_posterior_ess": 0.0, "regime_concordant": true }, { "cohort_id": "DEV-04", "split": "Development", "gene_symbol": "UNC13A (19p13.11 ALS/FTD)", "splice_event_label": "Intron 20โ€“21 Cryptic Exon (CE) Inclusion Upon TDP-43 Loss", "disease_or_cellular_context": "iPSC-Derived Human Cortical & Spinal Motor Neurons", "replicate_count": 3, "guide_count": 6, "copy_number_ratio": 1.0, "is_negative_control": false, "native_psi_cond1": 0.58, "native_psi_cond2": 0.0201, "native_delta_psi": 0.5599, "native_delta_psi_z": 2.4322, "native_isoform_entropy_cond1": 1.23, "native_isoform_entropy_cond2": 0.3349, "native_isoform_jsd_bits": 0.3398, "native_bagel_ln_bf_raw": -28.6176, "native_bagel_ln_bf_cn_adj": -28.6176, "native_posterior_essentiality": 0.0, "native_regime": "PathogenicExonSkippingOrCrypticInclusion", "scipy_psi_cond1": 0.58, "scipy_psi_cond2": 0.0201, "scipy_delta_psi": 0.5599, "scipy_delta_psi_z": 2.4322, "scipy_isoform_entropy_cond1": 1.23, "scipy_isoform_entropy_cond2": 0.3349, "scipy_isoform_jsd_bits": 0.3398, "scipy_bagel_ln_bf_raw": -28.6176, "scipy_bagel_ln_bf_cn_adj": -28.6176, "scipy_posterior_essentiality": 0.0, "scipy_regime": "PathogenicExonSkippingOrCrypticInclusion", "abs_diff_delta_psi": 0.0, "abs_diff_delta_psi_z": 0.0, "abs_diff_isoform_jsd": 0.0, "abs_diff_bagel_ln_bf": 0.0, "abs_diff_posterior_ess": 0.0, "regime_concordant": true }, { "cohort_id": "DEV-05", "split": "Development", "gene_symbol": "BCL2L1 (Bcl-xL / Bcl-xS)", "splice_event_label": "Exon 2 Distal vs. Proximal 5'ss Switch (Anti-Apoptotic Bcl-xL)", "disease_or_cellular_context": "Colorectal & Non-Small-Cell Lung Carcinoma Survival", "replicate_count": 3, "guide_count": 6, "copy_number_ratio": 1.0, "is_negative_control": false, "native_psi_cond1": 0.8217, "native_psi_cond2": 0.2621, "native_delta_psi": 0.5596, "native_delta_psi_z": 2.5819, "native_isoform_entropy_cond1": 0.8176, "native_isoform_entropy_cond2": 1.1272, "native_isoform_jsd_bits": 0.2511, "native_bagel_ln_bf_raw": 85.9842, "native_bagel_ln_bf_cn_adj": 85.9842, "native_posterior_essentiality": 1.0, "native_regime": "SpliceSwitchSyntheticLethalEssential", "scipy_psi_cond1": 0.8217, "scipy_psi_cond2": 0.2621, "scipy_delta_psi": 0.5596, "scipy_delta_psi_z": 2.5819, "scipy_isoform_entropy_cond1": 0.8176, "scipy_isoform_entropy_cond2": 1.1272, "scipy_isoform_jsd_bits": 0.2511, "scipy_bagel_ln_bf_raw": 85.9842, "scipy_bagel_ln_bf_cn_adj": 85.9842, "scipy_posterior_essentiality": 1.0, "scipy_regime": "SpliceSwitchSyntheticLethalEssential", "abs_diff_delta_psi": 0.0, "abs_diff_delta_psi_z": 0.0, "abs_diff_isoform_jsd": 0.0, "abs_diff_bagel_ln_bf": 0.0, "abs_diff_posterior_ess": 0.0, "regime_concordant": true }, { "cohort_id": "DEV-06", "split": "Development", "gene_symbol": "GAPDH / AAVS1 (Null Control)", "splice_event_label": "Constitutive Exon 5โ€“7 Junction & Safe-Harbor Non-Essential Control", "disease_or_cellular_context": "Isogenic Diploid RPE1 Baseline Control (0๐Ÿงช Negative Control)", "replicate_count": 3, "guide_count": 6, "copy_number_ratio": 1.0, "is_negative_control": true, "native_psi_cond1": 0.9603, "native_psi_cond2": 0.9569, "native_delta_psi": 0.0034, "native_delta_psi_z": 0.042, "native_isoform_entropy_cond1": 0.2747, "native_isoform_entropy_cond2": 0.3225, "native_isoform_jsd_bits": 0.0005, "native_bagel_ln_bf_raw": -34.3303, "native_bagel_ln_bf_cn_adj": -34.3303, "native_posterior_essentiality": 0.0, "native_regime": "NullHousekeepingIsoformNoiseControl", "scipy_psi_cond1": 0.9603, "scipy_psi_cond2": 0.9569, "scipy_delta_psi": 0.0034, "scipy_delta_psi_z": 0.042, "scipy_isoform_entropy_cond1": 0.2747, "scipy_isoform_entropy_cond2": 0.3225, "scipy_isoform_jsd_bits": 0.0005, "scipy_bagel_ln_bf_raw": -34.3303, "scipy_bagel_ln_bf_cn_adj": -34.3303, "scipy_posterior_essentiality": 0.0, "scipy_regime": "NullHousekeepingIsoformNoiseControl", "abs_diff_delta_psi": 0.0, "abs_diff_delta_psi_z": 0.0, "abs_diff_isoform_jsd": 0.0, "abs_diff_bagel_ln_bf": 0.0, "abs_diff_posterior_ess": 0.0, "regime_concordant": true }, { "cohort_id": "RES-01", "split": "UntouchedReserve", "gene_symbol": "WRN (8p12 RecQ Helicase)", "splice_event_label": "Exon 4โ€“5 Helicase ATP-Binding Isoform Usage in MSI-H vs. MSS", "disease_or_cellular_context": "Microsatellite-Instability-High (MSI-H) Colorectal & Endometrial Cancer", "replicate_count": 3, "guide_count": 6, "copy_number_ratio": 1.0, "is_negative_control": false, "native_psi_cond1": 0.8827, "native_psi_cond2": 0.3199, "native_delta_psi": 0.5628, "native_delta_psi_z": 2.6361, "native_isoform_entropy_cond1": 0.6267, "native_isoform_entropy_cond2": 1.314, "native_isoform_jsd_bits": 0.2567, "native_bagel_ln_bf_raw": 131.1959, "native_bagel_ln_bf_cn_adj": 131.1959, "native_posterior_essentiality": 1.0, "native_regime": "SpliceSwitchSyntheticLethalEssential", "scipy_psi_cond1": 0.8827, "scipy_psi_cond2": 0.3199, "scipy_delta_psi": 0.5628, "scipy_delta_psi_z": 2.6361, "scipy_isoform_entropy_cond1": 0.6267, "scipy_isoform_entropy_cond2": 1.314, "scipy_isoform_jsd_bits": 0.2567, "scipy_bagel_ln_bf_raw": 131.1959, "scipy_bagel_ln_bf_cn_adj": 131.1959, "scipy_posterior_essentiality": 1.0, "scipy_regime": "SpliceSwitchSyntheticLethalEssential", "abs_diff_delta_psi": 0.0, "abs_diff_delta_psi_z": 0.0, "abs_diff_isoform_jsd": 0.0, "abs_diff_bagel_ln_bf": 0.0, "abs_diff_posterior_ess": 0.0, "regime_concordant": true }, { "cohort_id": "RES-02", "split": "UntouchedReserve", "gene_symbol": "EZH2 (SRSF2-P95H Target)", "splice_event_label": "CCNG Enhancer-Driven Poison Exon 9.5 Inclusion (NMD)", "disease_or_cellular_context": "SRSF2-Mutant Chronic Myelomonocytic Leukemia & AML", "replicate_count": 3, "guide_count": 6, "copy_number_ratio": 1.0, "is_negative_control": false, "native_psi_cond1": 0.6206, "native_psi_cond2": 0.0889, "native_delta_psi": 0.5317, "native_delta_psi_z": 2.471, "native_isoform_entropy_cond1": 1.2199, "native_isoform_entropy_cond2": 0.7159, "native_isoform_jsd_bits": 0.2585, "native_bagel_ln_bf_raw": 90.3406, "native_bagel_ln_bf_cn_adj": 90.3406, "native_posterior_essentiality": 1.0, "native_regime": "SpliceSwitchSyntheticLethalEssential", "scipy_psi_cond1": 0.6206, "scipy_psi_cond2": 0.0889, "scipy_delta_psi": 0.5317, "scipy_delta_psi_z": 2.471, "scipy_isoform_entropy_cond1": 1.2199, "scipy_isoform_entropy_cond2": 0.7159, "scipy_isoform_jsd_bits": 0.2585, "scipy_bagel_ln_bf_raw": 90.3406, "scipy_bagel_ln_bf_cn_adj": 90.3406, "scipy_posterior_essentiality": 1.0, "scipy_regime": "SpliceSwitchSyntheticLethalEssential", "abs_diff_delta_psi": 0.0, "abs_diff_delta_psi_z": 0.0, "abs_diff_isoform_jsd": 0.0, "abs_diff_bagel_ln_bf": 0.0, "abs_diff_posterior_ess": 0.0, "regime_concordant": true }, { "cohort_id": "RES-03", "split": "UntouchedReserve", "gene_symbol": "STMN2 (8q21.13 Stathmin-2)", "splice_event_label": "Intron 1 Cryptic Exon 2a Premature Polyadenylation Upon TDP-43 Loss", "disease_or_cellular_context": "ALS Spinal Motor Neurons (Axonal Outgrowth & Regeneration)", "replicate_count": 3, "guide_count": 6, "copy_number_ratio": 1.0, "is_negative_control": false, "native_psi_cond1": 0.7412, "native_psi_cond2": 0.0294, "native_delta_psi": 0.7119, "native_delta_psi_z": 3.2234, "native_isoform_entropy_cond1": 1.0104, "native_isoform_entropy_cond2": 0.3874, "native_isoform_jsd_bits": 0.4761, "native_bagel_ln_bf_raw": -27.7504, "native_bagel_ln_bf_cn_adj": -27.7504, "native_posterior_essentiality": 0.0, "native_regime": "PathogenicExonSkippingOrCrypticInclusion", "scipy_psi_cond1": 0.7412, "scipy_psi_cond2": 0.0294, "scipy_delta_psi": 0.7119, "scipy_delta_psi_z": 3.2234, "scipy_isoform_entropy_cond1": 1.0104, "scipy_isoform_entropy_cond2": 0.3874, "scipy_isoform_jsd_bits": 0.4761, "scipy_bagel_ln_bf_raw": -27.7504, "scipy_bagel_ln_bf_cn_adj": -27.7504, "scipy_posterior_essentiality": 0.0, "scipy_regime": "PathogenicExonSkippingOrCrypticInclusion", "abs_diff_delta_psi": 0.0, "abs_diff_delta_psi_z": 0.0, "abs_diff_isoform_jsd": 0.0, "abs_diff_bagel_ln_bf": 0.0, "abs_diff_posterior_ess": 0.0, "regime_concordant": true }, { "cohort_id": "RES-04", "split": "UntouchedReserve", "gene_symbol": "CD19 (16p11.2 CART-19 Escape)", "splice_event_label": "SRSF3-Depleted Exon 2 Skipping (FMC63 Epitope Loss)", "disease_or_cellular_context": "Relapsed Pediatric B-Cell Acute Lymphoblastic Leukemia", "replicate_count": 3, "guide_count": 6, "copy_number_ratio": 1.0, "is_negative_control": false, "native_psi_cond1": 0.2204, "native_psi_cond2": 0.911, "native_delta_psi": -0.6906, "native_delta_psi_z": -3.2167, "native_isoform_entropy_cond1": 1.0653, "native_isoform_entropy_cond2": 0.5052, "native_isoform_jsd_bits": 0.3952, "native_bagel_ln_bf_raw": -32.6679, "native_bagel_ln_bf_cn_adj": -32.6679, "native_posterior_essentiality": 0.0, "native_regime": "PathogenicExonSkippingOrCrypticInclusion", "scipy_psi_cond1": 0.2204, "scipy_psi_cond2": 0.911, "scipy_delta_psi": -0.6906, "scipy_delta_psi_z": -3.2167, "scipy_isoform_entropy_cond1": 1.0653, "scipy_isoform_entropy_cond2": 0.5052, "scipy_isoform_jsd_bits": 0.3952, "scipy_bagel_ln_bf_raw": -32.6679, "scipy_bagel_ln_bf_cn_adj": -32.6679, "scipy_posterior_essentiality": 0.0, "scipy_regime": "PathogenicExonSkippingOrCrypticInclusion", "abs_diff_delta_psi": 0.0, "abs_diff_delta_psi_z": 0.0, "abs_diff_isoform_jsd": 0.0, "abs_diff_bagel_ln_bf": 0.0, "abs_diff_posterior_ess": 0.0, "regime_concordant": true }, { "cohort_id": "RES-05", "split": "UntouchedReserve", "gene_symbol": "PRPF8 (17p13.3 Core U5 snRNP)", "splice_event_label": "Constitutive Exon 38โ€“39 RNase-H/Jab1 Catalytic Spliceosome Core", "disease_or_cellular_context": "Pan-Cancer Core Essential Spliceosome Scaffold (DepMap)", "replicate_count": 3, "guide_count": 6, "copy_number_ratio": 1.0, "is_negative_control": false, "native_psi_cond1": 0.9502, "native_psi_cond2": 0.9371, "native_delta_psi": 0.0131, "native_delta_psi_z": 0.1441, "native_isoform_entropy_cond1": 0.3825, "native_isoform_entropy_cond2": 0.4671, "native_isoform_jsd_bits": 0.0015, "native_bagel_ln_bf_raw": 162.8149, "native_bagel_ln_bf_cn_adj": 162.8149, "native_posterior_essentiality": 1.0, "native_regime": "ConstitutiveCoreEssentialSplicingFactor", "scipy_psi_cond1": 0.9502, "scipy_psi_cond2": 0.9371, "scipy_delta_psi": 0.0131, "scipy_delta_psi_z": 0.1441, "scipy_isoform_entropy_cond1": 0.3825, "scipy_isoform_entropy_cond2": 0.4671, "scipy_isoform_jsd_bits": 0.0015, "scipy_bagel_ln_bf_raw": 162.8149, "scipy_bagel_ln_bf_cn_adj": 162.8149, "scipy_posterior_essentiality": 1.0, "scipy_regime": "ConstitutiveCoreEssentialSplicingFactor", "abs_diff_delta_psi": 0.0, "abs_diff_delta_psi_z": 0.0, "abs_diff_isoform_jsd": 0.0, "abs_diff_bagel_ln_bf": 0.0, "abs_diff_posterior_ess": 0.0, "regime_concordant": true }, { "cohort_id": "RES-06", "split": "UntouchedReserve", "gene_symbol": "PVT1 (8q24.21 CN=18 Amplicon Decoy)", "splice_event_label": "Non-Coding Exon 3โ€“4 Background Splicing in 18-Copy Focal Amplicon", "disease_or_cellular_context": "8q24-Amplified Cancer Line (Cas9 Multi-DSB Arrest Artifact, 0๐Ÿงช)", "replicate_count": 3, "guide_count": 6, "copy_number_ratio": 9.0, "is_negative_control": true, "native_psi_cond1": 0.5193, "native_psi_cond2": 0.504, "native_delta_psi": 0.0153, "native_delta_psi_z": 0.0685, "native_isoform_entropy_cond1": 1.4169, "native_isoform_entropy_cond2": 1.4406, "native_isoform_jsd_bits": 0.0003, "native_bagel_ln_bf_raw": 25.0596, "native_bagel_ln_bf_cn_adj": -32.9166, "native_posterior_essentiality": 0.0, "native_regime": "OffTargetCopyNumberAmplificationArtifactReject", "scipy_psi_cond1": 0.5193, "scipy_psi_cond2": 0.504, "scipy_delta_psi": 0.0153, "scipy_delta_psi_z": 0.0685, "scipy_isoform_entropy_cond1": 1.4169, "scipy_isoform_entropy_cond2": 1.4406, "scipy_isoform_jsd_bits": 0.0003, "scipy_bagel_ln_bf_raw": 25.0596, "scipy_bagel_ln_bf_cn_adj": -32.9166, "scipy_posterior_essentiality": 0.0, "scipy_regime": "OffTargetCopyNumberAmplificationArtifactReject", "abs_diff_delta_psi": 0.0, "abs_diff_delta_psi_z": 0.0, "abs_diff_isoform_jsd": 0.0, "abs_diff_bagel_ln_bf": 0.0, "abs_diff_posterior_ess": 0.0, "regime_concordant": true } ], "ascii_summary_chart": "============================================================================================================\n ALTERNATIVE SPLICING (PSI, dPSI, H_iso, JSD) & BAGEL2 CRISPR ESSENTIALITY CALIBRATION (VAL-SET-020)\n============================================================================================================\n Cohort Split Gene / Target PSI_1 PSI_2 dPSI JSD(b) lnBF_adj PP_ess Regime\n ----------------------------------------------------------------------------------------------------------\n DEV-01 DEV BRD9 (SF3B1-K700E Target) 0.6790 0.0692 +0.6098 0.3377 +102.8119 1.0000 SpliceSwitchSyntheticLethalEssential\n DEV-02 DEV SMN2 (5q13.2 SMA) 0.1800 0.8407 -0.6607 0.3534 +122.9770 1.0000 SpliceSwitchSyntheticLethalEssential\n DEV-03 DEV PKM (PKM1 Ex9 / PKM2 Ex10) 0.8604 0.1896 +0.6709 0.3682 +89.5401 1.0000 SpliceSwitchSyntheticLethalEssential\n DEV-04 DEV UNC13A (19p13.11 ALS/FTD) 0.5800 0.0201 +0.5599 0.3398 -28.6176 0.0000 PathogenicExonSkippingOrCrypticInclusion\n DEV-05 DEV BCL2L1 (Bcl-xL / Bcl-xS) 0.8217 0.2621 +0.5596 0.2511 +85.9842 1.0000 SpliceSwitchSyntheticLethalEssential\n DEV-06 DEV GAPDH / AAVS1 (Null Control) 0.9603 0.9569 +0.0034 0.0005 -34.3303 0.0000 NullHousekeepingIsoformNoiseControl\n RES-01 RESERVE WRN (8p12 RecQ Helicase) 0.8827 0.3199 +0.5628 0.2567 +131.1959 1.0000 SpliceSwitchSyntheticLethalEssential\n RES-02 RESERVE EZH2 (SRSF2-P95H Target) 0.6206 0.0889 +0.5317 0.2585 +90.3406 1.0000 SpliceSwitchSyntheticLethalEssential\n RES-03 RESERVE STMN2 (8q21.13 Stathmin-2) 0.7412 0.0294 +0.7119 0.4761 -27.7504 0.0000 PathogenicExonSkippingOrCrypticInclusion\n RES-04 RESERVE CD19 (16p11.2 CART-19 Escape 0.2204 0.9110 -0.6906 0.3952 -32.6679 0.0000 PathogenicExonSkippingOrCrypticInclusion\n RES-05 RESERVE PRPF8 (17p13.3 Core U5 snRNP 0.9502 0.9371 +0.0131 0.0015 +162.8149 1.0000 ConstitutiveCoreEssentialSplicingFactor\n RES-06 RESERVE PVT1 (8q24.21 CN=18 Amplicon 0.5193 0.5040 +0.0153 0.0003 -32.9166 0.0000 OffTargetCopyNumberAmplificationArtifactReject\n============================================================================================================\n" }